Überführung eines in XML definierten applikationsneutralen Schnittstellenmodells für Bordnetzdaten mittels XSLT in das standartisierte Graphikformat SVG

Für die Verbesserung und Unterstützung des Bordnetzentwicklungsprozesses wurde besprochen, Bordnetzentwicklungsdaten in einem standardisierten Format applikationsneutral zu halten und verschiedene Sichten auf diese Informationen zu erzeugen. Hierbei sind folgende Fragen zu beantworten. • Ist es möglich, Bordnetzdaten in XML applikationsneutral abzubilden und zu halten? • Sind verschiedene Sichten auf das Bordnetz ableitbar? • Sind XML und XSLT für die Speicherung und Aufbereitung der Bordnetzinformationen geeignet? • Ist XML als alleiniges natives Datenformat in der Bordnetzentwicklung geeignet? Zur Beantwortung dieser Fragen soll ein Prototyp realisiert werden. Mit Hilfe dieser prototypischen, entwicklungsbegleitenden Plattform soll die Generierung verschiedener Sichten auf Bordnetzdaten ermöglicht werden. Dabei wird der Fokus auf der dynamischen Generierung von Schaltplänen in SVG liegen. Beispielhaft soll die Durchführung einer dynamischen Analyse und eines Reports erfolgen. Darunter sind ebenfalls Sichtgenerierungen zu verstehen, wobei Bordnetzinformationen für Auswertungszwecke extrahiert und in übersichtlicher Form dargestellt werden sollen

Infrastrukturen und Services für die wissenschaftliche Nutzung von Webarchiven: Ein Überblick

Der Beitrag gibt zunächst einen kurzen Überblick über den aktuellen Stand der Webarchivierung in deutschen Bibliotheken und beleuchtet dabei auch die rechtlichen Rahmenbedingungen. Darauf aufbauend werden die derzeitige Praxis der Erschließung und Nutzung von Webarchiven sowie die Anforderungen an die Dokumentation der Prozesse der Webarchivierung beschrieben. Eine zusammenfassende Analyse von weitergehenden Formen der Datenbereitstellung aus Webarchiven sowie von unterstützenden Services zur wissenschaftlichen Nutzung mit computergestützten Analysemethoden anhand von Beispielen aus der internationalen Webarchivierungs-Community bildet den Schwerpunkt des Artikels.  The article first gives a brief overview of the current state of web archiving in German libraries and also sheds light on the legal framework. Based on this, the current practice of indexing and using web archives as well as the requirements for the documentation of web archiving processes are described. The focus of the article is a comprehensive analysis of additional forms of data provision from web archives and of supporting services for scientific use with computer-aided analysis methods using examples from the international web archiving community.

Religion and Popular Music

The interactions between popular music and religion are manyfold and highly complex. Popular music as an important part of popular culture is a means of communication. Music can transmit not only emotions and a sense of community but also religious knowledge, knowledge that leaves diverse traces in different times and places. In the end, whether we extract religious meaning from popular music and what that meaning is depend on our background and on our capacity to contextualise symbols, motives and narratives – and also on the media used to convey these references. By analysing Florence + The Machines song “Big God” and its music video we will address some of the questions that arise while working in the field of popular music and religion

Enantio- and Diastereoselective Access to Distant Stereocenters Embedded within Tetrahydroxanthenes : Utilizing ortho-Quinone Methides as Reactive Intermediates in Asymmetric Brønsted Acid Catalysis

Background: Complex small supernumerary marker chromosomes (sSMC) constitute one of the smallest subgroups of sSMC in general. Complex sSMC consist of chromosomal material derived from more than one chromosome; the best known representative of this group is the derivative chromosome 22 {der(22)t(11;22)} or Emanuel syndrome. in 2008 we speculated that complex sSMC could be part of an underestimated entity.Results: Here, the overall yet reported 412 complex sSMC are summarized. They constitute 8.4% of all yet in detail characterized sSMC cases. the majority of the complex sSMC is contributed by patients suffering from Emanuel syndrome (82%). Besides there are a der(22)t(8;22)(q24.1;q11.1) and a der(13)t(13;18)(q11;p11.21) or der(21)t(18;21) (p11.21;q11.1) = der(13 or 21)t(13 or 21;18) syndrome. the latter two represent another 2.6% and 2.2% of the complex sSMC-cases, respectively. the large majority of complex sSMC has a centric minute shape and derives from an acrocentric chromosome. Nonetheless, complex sSMC can involve material from each chromosomal origin. Most complex sSMC are inherited form a balanced translocation in one parent and are non-mosaic. Interestingly, there are hot spots for the chromosomal breakpoints involved.Conclusions: Complex sSMC need to be considered in diagnostics, especially in non-mosaic, centric minute shaped sSMC. As yet three complex-sSMC-associated syndromes are identified. As recurrent breakpoints in the complex sSMC were characterized, it is to be expected that more syndromes are identified in this subgroup of sSMC. Overall, complex sSMC emphasize once more the importance of detailed cytogenetic analyses, especially in patients with idiopathic mental retardation

High-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey.

BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement therapy. Data on the outcomes of HU transplantation are sparse and the benefit is controversial. METHODS: We systematically analysed data from 898 ET HU kidney transplant recipients from 61 transplant centres between 1996 and 2010 and investigated the 5-year patient and graft outcomes and differences between relevant subgroups. RESULTS: Kidney recipients with an HU status were younger (median 43 versus 55 years) and spent less time on the waiting list compared with non-HU recipients (34 versus 54 months). They received grafts with significantly more mismatches (mean 3.79 versus 2.42; P < 0.001) and the percentage of retransplantations was remarkably higher (37.5 versus 16.7%). Patient survival (P = 0.0053) and death with a functioning graft (DwFG; P < 0.0001) after HU transplantation were significantly worse than in non-HU recipients, whereas graft outcome was comparable (P = 0.094). Analysis according to the different HU indications revealed that recipients listed HU because of an imminent lack of access for dialysis had a significantly worse patient survival (P = 0.0053) and DwFG (P = 0.0462) compared with recipients with psychological problems and suicidality because of dialysis. In addition, retransplantation had a negative impact on patient and graft outcome. CONCLUSIONS: Facing organ shortages, increasing wait times and considerable mortality on dialysis, we question the current policy of HU allocation and propose more restrictive criteria with regard to individuals with vascular complications or repeated retransplantations in order to support patients on the non-HU waiting list with a much better long-term prognosis

Repeated kidney re‐transplantation—the Eurotransplant experience: a retrospective multicenter outcome analysis

In Eurotransplant kidney allocation system (ETKAS), candidates can be considered unlimitedly for repeated re-transplantation. Data on outcome and benefit are indeterminate. We performed a retrospective 15-year patient and graft outcome data analysis from 1464 recipients of a third or fourth or higher sequential deceased donor renal transplantation (DDRT) from 42 transplant centers. Repeated re-DDRT recipients were younger (mean 43.0 vs. 50.2 years) compared to first DDRT recipients. They received grafts with more favorable HLA matches (89.0% vs. 84.5%) but thereby no statistically significant improvement of patient and graft outcome was found as comparatively demonstrated in 1st DDRT. In the multivariate modeling accounting for confounding factors, mortality and graft loss after 3rd and >= 4th DDRT (P = 4th DDRT

Repeated kidney re-transplantation-the Eurotransplant experience: a retrospective multicenter outcome analysis

In Eurotransplant kidney allocation system (ETKAS), candidates can be considered unlimitedly for repeated re-transplantation. Data on outcome and benefit are indeterminate. We performed a retrospective 15-year patient and graft outcome data analysis from 1464 recipients of a third or fourth or higher sequential deceased donor renal transplantation (DDRT) from 42 transplant centers. Repeated re-DDRT recipients were younger (mean 43.0 vs. 50.2 years) compared to first DDRT recipients. They received grafts with more favorable HLA matches (89.0% vs. 84.5%) but thereby no statistically significant improvement of patient and graft outcome was found as comparatively demonstrated in 1st DDRT. In the multivariate modeling accounting for confounding factors, mortality and graft loss after 3rd and ≥4th DDRT (P < 0.001 each) and death with functioning graft (DwFG) after 3rd DDRT (P = 0.001) were higher as compared to 1st DDRT. The incidence of primary nonfunction (PNF) was also significantly higher in re-DDRT (12.7%) than in 1st DDRT (7.1%; P < 0.001). Facing organ shortage, increasing waiting time, and considerable mortality on dialysis, we question the current policy of repeated re-DDRT. The data from this survey propose better HLA matching in first DDRT and second DDRT and careful selection of candidates, especially for ≥4th DDRT.status: publishe

Kidney Transplantation After Rescue Allocation-the Eurotransplant Experience:A Retrospective Multicenter Outcome Analysis

BACKGROUND: At Eurotransplant (ET), kidneys are transferred to 'rescue allocation' (RA), whenever the standard allocation (SA) algorithms Eurotransplant kidney allocation system (ETKAS) and Eurotransplant senior program (ESP) fail. We analyzed the outcome of RA. METHODS: Retrospective patient clinical and demographic characteristics association analyses with graft outcomes for 2,421 recipients of a deceased donor renal transplantation (DDRT) after RA versus 25,475 after SA from 71 centers across all ET countries from 2006 to 2018. RESULTS: Numbers of DDRTs after RA increased over the time, especially in Germany. RA played a minor role in ESP vs. ETKAS (2.7% vs. 10.4%). RA recipients and donors were older compared to SA recipients and donors, cold ischemia times were longer, waiting times were shorter, and the incidence of primary non-function was comparable. Among ETKAS-recipients, HLA matching was more favorable in SA (mean 3.7 vs. 2.5). In multivariate modeling, the incidence of death with a functioning graft (DwFG) in ETKAS was reduced in RA compared to SA (subdistribution hazard ratio 0.70, 95% confidence interval [0.60-0.81], p<0.001) whereas other outcomes (mortality, graft loss) were not significantly different. None of the three outcomes were significantly different when comparing RA with SA within the ESP program. CONCLUSIONS: Facing increased waiting times and mortality on dialysis due to donor shortage, this study reveals encouragingly positive DDRT outcomes following RA. This supports the extension of RA to more patients and as an alternative tool to enable transplantation in patients in countries with prohibitively long waiting times or at risk of deterioration.Supplemental Visual Abstract; http://links.lww.com/TP/C297